BI 2536
BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.
| Trivial name | N/A |
| Catalog Number | S1109 |
| Molecular Formula | C28H39N7O3 |
| CAS# | 755038-02-9 |
| Inchi | InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31, 32)/t22-/m1/s1 |
| Inchi Key | XQVVPGYIWAGRNI-JOCHJYFZSA-N |
| SMILES | CCC1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/BI-2536.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BI-2536-chemical-structure-S1109.gif |