Regorafenib
Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. Regorafenib induces autophagy.
| Trivial name | Fluoro-Sorafenib, BAY 73-4506 |
| Catalog Number | S1178 |
| Molecular Formula | C20H20ClN5O2 |
| CAS# | 755037-03-7 |
| Inchi | InChI=1S/C20H20ClN5O2/c21-15-3-1-13(2-4-15)19-18(16-5-8-22-12-23-16)20(25-24-19)14-6-9-26(10-7-14)17(28)11-27/h1-5,8,12,14,27H,6-7,9-11H2,(H,24,25) |
| Inchi Key | CATQHDWESBRRQA-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1C2=C(C(=NN2)C3=CC=C(C=C3)Cl)C4=NC=NC=C4)C(=O)CO |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/BAY-73-4506.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BAY-73-4506-chemical-structure-s1178.gif |