Regorafenib
Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. Regorafenib induces autophagy.
| Trivial name | Fluoro-Sorafenib, BAY 73-4506 |
| Catalog Number | S1178 |
| Molecular Formula | C22H19ClN2O6S |
| CAS# | 755037-03-7 |
| Inchi | InChI=1S/C22H19ClN2O6S/c1-29-19-9-7-15(23)11-18(19)25(32(27,28)17-5-3-2-4-6-17)13-22(26)24-16-8-10-20-21(12-16)31-14-30-20/h2-12H,13-14H2,1H3,(H,24,26) |
| Inchi Key | ZGYSGIYKAVUVOR-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C=C1)Cl)N(CC(=O)NC2=CC3=C(C=C2)OCO3)S(=O)(=O)C4=CC=CC=C4 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/BAY-73-4506.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BAY-73-4506-chemical-structure-s1178.gif |