Regorafenib
Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. Regorafenib induces autophagy.
| Trivial name | Fluoro-Sorafenib, BAY 73-4506 |
| Catalog Number | S1178 |
| Molecular Formula | C25H25Cl2FN6O3 |
| CAS# | 755037-03-7 |
| Inchi | InChI=1S/C25H25Cl2FN6O3/c1-14(21-17(26)7-8-18(28)22(21)27)37-20-13-19(31-32-23(20)29)24(35)30-16-5-3-15(4-6-16)25(36)34-11-9-33(2)10-12-34/h3-8,13-14H,9-12H2,1-2H3,(H2,29,32)(H,30,35)/t14-/m1/s1 |
| Inchi Key | ONPGOSVDVDPBCY-CQSZACIVSA-N |
| SMILES | CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=CC(=NN=C2N)C(=O)NC3=CC=C(C=C3)C(=O)N4CCN(CC4)C |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/BAY-73-4506.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BAY-73-4506-chemical-structure-s1178.gif |