Luminespib (NVP-AUY922)

Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.

Price Not Available 10mM/1mL Luminespib (NVP-AUY922) Supplier Page

Trivial name	AUY-922, VER-52296
Catalog Number	S1069
Molecular Formula	C26H31N3O5
CAS#	747412-49-3
Inchi	InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32)
Inchi Key	NDAZATDQFDPQBD-UHFFFAOYSA-N
SMILES	CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/NVP-AUY922.html
Additional Information	https://file.selleck.cn/downloads/struct/AUY922-chemical-structure-S1069.gif