R547
R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.
| Trivial name | Ro 4584820 |
| Catalog Number | S2688 |
| Molecular Formula | C18H21F2N5O4S |
| CAS# | 741713-40-6 |
| Inchi | InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24) |
| Inchi Key | JRNJNYBQQYBCLE-UHFFFAOYSA-N |
| SMILES | COC1=C(C(=C(C=C1)F)F)C(=O)C2=CN=C(N=C2N)NC3CCN(CC3)S(=O)(=O)C |
| Size | 2mg |
| Supplier Page | http://www.selleckchem.com/products/r547.html |
| Additional Information | https://file.selleck.cn/downloads/struct/R547-chemical-structure-s2688.gif |