tetrabenazine
Tetrabenazine (Ro 1-9569) is a non-competitive inhibitor of the vesicular monoamine transporter (VMAT), with a higher selectivity for VMAT2 over VMAT1. It exhibits an IC50 of 0.3 µM for VMAT2 and 3 µM for VMAT1, and a Kd of 60 nM for VMAT2 and 9.38 nM for VMAT1. It treats Huntington’s chorea by reducing excessive dopaminergic activity and impairing monoamine storage in synaptic vesicles.
| Trivial name | Ro 1-9569 |
| Catalog Number | E6053 |
| Molecular Formula | C17H19FN4O2S |
| CAS# | 718635-93-9 |
| Inchi | InChI=1S/C17H19FN4O2S/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24)/t12-/m0/s1 |
| Inchi Key | IAYGCINLNONXHY-LBPRGKRZSA-N |
| SMILES | C1CC(CNC1)NC(=O)C2=C(C=C(S2)C3=CC(=CC=C3)F)NC(=O)N |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/tetrabenazine.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E6053-tetrabenazine-chemical-structure.png |