PF-562271
PF-562271 (PF-00562271) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
| Trivial name | PF-00562271 |
| Catalog Number | S2890 |
| Molecular Formula | C25H32O13 |
| CAS# | 717907-75-0 |
| Inchi | InChI=1S/C25H32O13/c1-3-13-14(9-19(29)35-7-6-12-4-5-16(27)17(28)8-12)15(23(33)34-2)11-36-24(13)38-25-22(32)21(31)20(30)18(10-26)37-25/h3-5,8,11,14,18,20-22,24-28,30-32H,6-7,9-10H2,1-2H3/b13-3+/t14-,18 +,20+,21-,22+,24-,25-/m0/s1 |
| Inchi Key | RFWGABANNQMHMZ-ZCHJGGQASA-N |
| SMILES | CC=C1C(C(=COC1OC2C(C(C(C(O2)CO)O)O)O)C(=O)OC)CC(=O)OCCC3=CC(=C(C=C3)O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/pf-562271.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PF-562271-chemical-structure-s2890.jpg |