Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39?μM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow[2].In Vitro:Veratridine (0.25 mM and 1 mM; 24 h) treatment results in all cells death[2].
Veratridine (0.001-100 μM) produces tetrodotoxin-sensitive responses.