Ivermectin
Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.
| Trivial name | MK-933 |
| Catalog Number | S1351 |
| Molecular Formula | C27H44O3 |
| CAS# | 70288-86-7 |
| Inchi | InChI=1S/C27H44O3/c1-18(8-9-19(2)26(3,4)30)24-12-13-25-21(7-6-14-27(24,25)5)11-10-20-15-22(28)17-23(29)16-20/h8-11,18-19,22-25,28-30H,6-7,12-17H2,1-5H3/b9-8+,21-11+/t18-,19+,22-,23-,24-,25+,27-/m1/s1 |
| Inchi Key | BPKAHTKRCLCHEA-UBFJEZKGSA-N |
| SMILES | CC(C=CC(C)C(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3)O)O)C |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/Ivermectin.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Ivermectin-chemical-structure-S1351.gif |