BX-795
BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.
| Trivial name | N/A |
| Catalog Number | S1274 |
| Molecular Formula | C23H26IN7O2S |
| CAS# | 702675-74-9 |
| Inchi | InChI=1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30) |
| Inchi Key | VAVXGGRQQJZYBL-UHFFFAOYSA-N |
| SMILES | C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/bx-795.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BX-795-chemical-structure-s1274.gif |