BX-912
BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM, 9- and 105- fold greater selectivity for PDK1 than PKA and PKC in cell-free assays, respectively. In comparison to GSK3β, selectivity for PDK1 is 600-fold.
| Trivial name | N/A |
| Catalog Number | S1275 |
| Molecular Formula | C21H20FN3O4 |
| CAS# | 702674-56-4 |
| Inchi | InChI=1S/C21H20FN3O4/c22-15-3-1-13(2-4-15)11-14-7-9-25(10-8-14)20(27)19(26)23-16-5-6-17-18(12-16)29-21(28)24-17/h1-6,12,14H,7-11H2,(H,23,26)(H,24,28) |
| Inchi Key | GKGRZLGAQZPEHO-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1CC2=CC=C(C=C2)F)C(=O)C(=O)NC3=CC4=C(C=C3)NC(=O)O4 |
| Size | 2mg |
| Supplier Page | http://www.selleckchem.com/products/bx-912.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BX-912-chemical-structure-s1275.gif |