LY2109761
LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis.
| Trivial name | N/A |
| Catalog Number | S2704 |
| Molecular Formula | C9H9BrN2O3 |
| CAS# | 700874-71-1 |
| Inchi | InChI=1S/C9H9BrN2O3/c10-6-1-2-7(11-5-6)12-8(13)3-4-9(14)15/h1-2,5H,3-4H2,(H,14,15)(H,11,12,13) |
| Inchi Key | XFYYQDHEDOXWGA-UHFFFAOYSA-N |
| SMILES | C1=CC(=NC=C1Br)NC(=O)CCC(=O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/ly2109761.html |
| Additional Information | https://file.selleck.cn/downloads/struct/LY2109761-chemical-structure-s2704.gif |