LY2109761
LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis.
| Trivial name | N/A |
| Catalog Number | S2704 |
| Molecular Formula | C26H27N5O2 |
| CAS# | 700874-71-1 |
| Inchi | InChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2 |
| Inchi Key | IHLVSLOZUHKNMQ-UHFFFAOYSA-N |
| SMILES | C1CC2=C(C(=NN2C1)C3=CC=CC=N3)C4=C5C=CC(=CC5=NC=C4)OCCN6CCOCC6 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/ly2109761.html |
| Additional Information | https://file.selleck.cn/downloads/struct/LY2109761-chemical-structure-s2704.gif |