Neratinib
Neratinib is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.
| Trivial name | HKI-272 |
| Catalog Number | S2150 |
| Molecular Formula | C25H20N4O2S2 |
| CAS# | 698387-09-6 |
| Inchi | InChI=1S/C25H20N4O2S2/c30-22(28-21-12-11-18(15-26-21)17-7-3-1-4-8-17)16-33-25-27-20-13-14-32-23(20)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,26,28,30) |
| Inchi Key | QESQGTFWEQMCMH-UHFFFAOYSA-N |
| SMILES | C1CSC2=C1N=C(N(C2=O)C3=CC=CC=C3)SCC(=O)NC4=NC=C(C=C4)C5=CC=CC=C5 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/Neratinib(HKI-272).html |
| Additional Information | https://file.selleck.cn/downloads/struct/Neratinib-HKI-272-chemical-structure-S2150.gif |