Neratinib
Neratinib is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.
| Trivial name | HKI-272 |
| Catalog Number | S2150 |
| Molecular Formula | C30H29ClN6O3 |
| CAS# | 698387-09-6 |
| Inchi | InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9- 7+ |
| Inchi Key | JWNPDZNEKVCWMY-VQHVLOKHSA-N |
| SMILES | CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/Neratinib(HKI-272).html |
| Additional Information | https://file.selleck.cn/downloads/struct/Neratinib-HKI-272-chemical-structure-S2150.gif |