CYC116
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.
| Trivial name | N/A |
| Catalog Number | S1171 |
| Molecular Formula | C18H20N6OS |
| CAS# | 693228-63-6 |
| Inchi | InChI=1S/C18H20N6OS/c1-12-16(26-17(19)21-12)15-6-7-20-18(23-15)22-13-2-4-14(5-3-13)24-8-10-25-11-9-24/h2-7H,8-11H2,1H3,(H2,19,21)(H,20,22,23) |
| Inchi Key | GPSZYOIFQZPWEJ-UHFFFAOYSA-N |
| SMILES | CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4 |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/CYC116.html |
| Additional Information | https://file.selleck.cn/downloads/struct/CYC116-chemical-structure-S1171.gif |