Nutlin-3b
Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
| Trivial name | (+)-Nutlin-3 |
| Catalog Number | S8065 |
| Molecular Formula | C30H30Cl2N4O4 |
| CAS# | 675576-97-3 |
| Inchi | InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27- ,28+/m1/s1 |
| Inchi Key | BDUHCSBCVGXTJM-IZLXSDGUSA-N |
| SMILES | CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/nutlin-3b.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Nutlin-3b-chemical-structure-s8065.gif |