Crenolanib
Crenolanib is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.
| Trivial name | CP-868596, ARO 002 |
| Catalog Number | S2730 |
| Molecular Formula | C26H29N5O2 |
| CAS# | 670220-88-9 |
| Inchi | InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3 |
| Inchi Key | DYNHJHQFHQTFTP-UHFFFAOYSA-N |
| SMILES | CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/crenolanib-cp-868596.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Crenolanib-chemical-structure-s2730.gif |