10,12-Tricosadiynoic acid
10,12-Tricosadiynoic acid is a highly specific, selective, high-affinity, and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1), it enhances hepatic mitochondrial FAO via the SIRT1-AMPK pathway and PPARα activation. It also reduces liver lipids, ROS accumulation, and insulin resistance, indicating its potential for treating metabolic diseases such as fatty liver, hypertriglyceridemia, and possibly diabetes.
Catalog Number | E7585 |
Molecular Formula | C29H41F2N5O |
CAS# | 66990-30-5 |
Inchi | InChI=1S/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23?,24?,25?,26-/m0/s1 |
Inchi Key | GSNHKUDZZFZSJB-ILVMPNSOSA-N |
SMILES | CC1=NN=C(N1C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C |
Size | 5mg |
Supplier Page | http://www.selleckchem.com/products/10-12-tricosadiynoic-acid.html |
Additional Information | https://file.selleck.cn/downloads/struct/E7585-10-12-Tricosadiynoic-acid-chemical-structure.png |