Indirubin-3′-oxime
Indirubin-3′-oxime (IDR3O, I3O) is an indirubin analogue that shows favorable inhibitory activity targeting GSK-3β and CDKs. Indirubin-3′-oxime also inhibits JNKs with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM for JNK1, JNK2, and JNK3, respectively. Indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity.
| Trivial name | IDR3O, I3O |
| Catalog Number | E0072 |
| Molecular Formula | C₁₆H₁₁N₃O₂ |
| CAS# | 667463-82-3 |
| SMILES | O\N=C1\C(NC2=CC=CC=C12)=C/3C(=O)NC4=CC=CC=C34 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/indirubin-3-oxime.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e0072-indirubin-3-oxime-chemical-structure.gif |