Motixafortide (BL-8040)
Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of CXCR4 with IC50 of ～1 nM. BL-8040 induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.
| Trivial name | BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140 |
| Catalog Number | S9665 |
| Molecular Formula | C97H144FN33O19S2 |
| CAS# | 664334-36-5 |
| SMILES | C1CC2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2C1)CCCCN)CCCCN)CCCNC(=O)N)CC3=CC=C(C=C3)O)NC(=O)C(CC4=CC5=CC=CC=C5C=C4)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C6=CC=C(C=C6)F)C(=O)NC(CCCNC(=N)N)C(=O)N)CCCNC(=O)N)CCCNC(=N)N)CC7=CC=C(C=C7)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/motixafortide-bl-8040-.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s9665-motixafortide-bl-8040--chemical-structure.gif |