Nintedanib
Nintedanib is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM in cell-free assays. Phase 3.
| Trivial name | BIBF 1120, Intedanib |
| Catalog Number | S1010 |
| Molecular Formula | C31H33N5O4 |
| CAS# | 656247-17-5 |
| Inchi | InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28- |
| Inchi Key | XZXHXSATPCNXJR-ZIADKAODSA-N |
| SMILES | CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/BIBF1120.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BIBF1120-Vargatef-chemical-structure-S1010.gif |