UTL-5g| ChemScene

UTL-5g (GBL-5g), an anti-inflammatory TNF-α inhibitor, has chemoprotective and liver radioprotective effects. UTL-5g lowers hepatotoxicity, nephrotoxicity, and myelotoxicity induced by Cisplatin through TNF-α inhibition among other factors[2].In Vitro: RAW 264.7 macrophages are transfected with the respective reporter assay plasmids, pretreated with UTL-5g at 1, 10 or 50 μM for 60 min and then challenged with 100 ng/ml LPS. After a 16 h incubation, transcription factor activity is measured. Transcription factors that shows a UTL-5g dose-dependent decrease in activity in two experiments are categorized as being disrupted by UTL-5g.In Vivo: UTL-5g (GBL-5g) lowers levels of TGF-β and TNF-α elevated by lung irradiation.
UTL-5g (60 mg/kg; p.o.; daily for 4 days) shows positive effects in increasing the survival rates and extending the survival times.

Price Not Available 100mg UTL-5g| ChemScene Supplier Page
Trivial name UTL-5g
Catalog Number CS-0063671
Alternative Name(s) GBL-5g
Molecular Formula 271.10
CAS# 646530-37-2
Purity >98%
Condensed Formula C11H8Cl2N2O2
Size 100mg
Supplier Page www.chemscene.com/646530-37-2.html