Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle.IC50 & Target: Ki: 7.10 nM (β-adrenergic receptor)In Vitro: Oxprenolol is lipophilic.
Oxprenolol shows permeability rate constant of 1.54 ± 1.54×10-3 cm/h across abdominal human skin.In Vivo: Oxprenolol (200 mg/kg/day; p.o.; daily for 3 weeks) produces effective beta-blockade[2].