Nilotinib
Nilotinib is a selective Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.
| Trivial name | AMN-107 |
| Catalog Number | S1033 |
| Molecular Formula | C28H22F3N7O |
| CAS# | 641571-10-0 |
| Inchi | InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37) |
| Inchi Key | HHZIURLSWUIHRB-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/Nilotinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Nilotinib-AMN-107-chemical-structure-S1033.gif |