GANT58
Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC50 ~ 5 µM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.
| Catalog Number | ABS-017 |
| Alternative Name(s) | 2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503 |
| CAS# | 64048-12-0 |
| Inchi | InChI=1S/C24H16N4S/c1-9-25-10-2-17(1)21-22(18-3-11-26-12-4-18)24(20-7-15-28-16-8-20)29-23(21)19-5-13-27-14-6-19/h1-16H |
| Inchi Key | USWLOKMMUTWFMD-UHFFFAOYSA-N |
| SMILES | C1=CN=CC=C1C2=C(SC(=C2C3=CC=NC=C3)C4=CC=NC=C4)C5=CC=NC=C5 |
| Size | Inquiry |
| Supplier Page | https://www.agingclocks.com/gant58-item-1483.html |