Tozasertib (VX-680)

Tozasertib (VX-680) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy. Phase 2.

Price Not Available 25mg Tozasertib (VX-680) Supplier Page

Trivial name	MK-0457
Catalog Number	S1048
Molecular Formula	C16H10N2Na2O7S2
CAS#	639089-54-6
Inchi	InChI=1S/C16H12N2O7S2.2Na/c19-15-8-1-10-9-13(27(23,24)25)6-7-14(10)16(15)18-17-11-2-4-12(5-3-11)26(20,21)22;;/h1-9,19H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2/b18-17+;;
Inchi Key	OIQPTROHQCGFEF-QIKYXUGXSA-L
SMILES	C1=CC(=CC=C1N=NC2=C(C=CC3=C2C=CC(=C3)S(=O)(=O)[O-])O)S(=O)(=O)[O-].[Na+].[Na+]
Size	25mg
Supplier Page	http://www.selleckchem.com/products/VX-680(MK-0457).html
Additional Information	https://file.selleck.cn/downloads/struct/VX-680-MK-0457-chemical-structure-S1048.gif