Tozasertib (VX-680)

Tozasertib (VX-680) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy. Phase 2.

Price Not Available 10mM/1mL Tozasertib (VX-680) Supplier Page

Trivial name	MK-0457
Catalog Number	S1048
Molecular Formula	C8H14O2
CAS#	639089-54-6
Inchi	InChI=1S/C8H14O2/c1-2-3-4-5-6-7-8(9)10/h6-7H,2-5H2,1H3,(H,9,10)/b7-6+
Inchi Key	CWMPPVPFLSZGCY-VOTSOKGWSA-N
SMILES	CCCCCC=CC(=O)O
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/VX-680(MK-0457).html
Additional Information	https://file.selleck.cn/downloads/struct/VX-680-MK-0457-chemical-structure-S1048.gif