Gliocidin
Gliocidin (SW106065), is a nicotinamide-mimetic prodrug that targets glioblastoma cells with an IC50 of 150 nM, by exploiting a de novo purine synthesis vulnerability via indirect inhibition of IMPDH2. It readily crosses the BBB and can be used in the treatment of all malignant brain tumors.
| Trivial name | SW106065 |
| Catalog Number | E5804 |
| Molecular Formula | C17H27N3O4S |
| CAS# | 62289-81-0 |
| Inchi | InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21) |
| Inchi Key | NTJOBXMMWNYJFB-UHFFFAOYSA-N |
| SMILES | CCN1CCCC1CNC(=O)C2=CC(=C(C=C2OC)N)S(=O)(=O)CC |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/gliocidin.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5804-Gliocidin-chemical-structure.png |