Hydroxycitric acid, a natural product isolated and purified from the fruits of Garcinia atroviridis, can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis, and ameliorate high-fructose-induced redox imbalance and activation of stress sensitive kinases in male Wistar rats through its hypolipidemic effects.