Binimetinib (MEK162)

Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy. Phase 3.

Price Not Available 1g Binimetinib (MEK162) Supplier Page

Trivial name	ARRY-162,ARRY-438162
Catalog Number	S7007
Molecular Formula	C17H15BrF2N4O3
CAS#	606143-89-9
Inchi	InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
Inchi Key	ACWZRVQXLIRSDF-UHFFFAOYSA-N
SMILES	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO
Size	1g
Supplier Page	http://www.selleckchem.com/products/mek162.html
Additional Information	https://file.selleck.cn/downloads/struct/MEK162-chemical-structure-s7007.gif