Selumetinib (AZD6244)

Selumetinib (AZD6244, ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Selumetinib suppresses cell proliferation, migration and trigger apoptosis. Phase 3.

Price Not Available 500mg Selumetinib (AZD6244) Supplier Page

Trivial name	ARRY-142886
Catalog Number	S1008
Molecular Formula	C7H6O5
CAS#	606143-52-6
Inchi	InChI=1S/C7H6O5/c8-4-2-1-3(7(11)12)5(9)6(4)10/h1-2,8-10H,(H,11,12)
Inchi Key	BRRSNXCXLSVPFC-UHFFFAOYSA-N
SMILES	C1=CC(=C(C(=C1C(=O)O)O)O)O
Size	500mg
Supplier Page	http://www.selleckchem.com/products/AZD6244.html
Additional Information	https://file.selleck.cn/downloads/struct/AZD6244-Selumetinib-chemical-structure-S1008.gif