NBI 35965 methanesulfonate | MedChemExpress (MCE)
NBI 35965 methanesulfonate is a selective, orally active and brain-penetrant corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki value of 4 nM and a pKi value of 8.5. NBI 35965 methanesulfonate does not inhibit CRF2. NBI 35965 methanesulfonate reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 methanesulfonate shows anxiolytic effects[1][2].
| Trivial name | NBI 35965 methanesulfonate |
| Catalog Number | HY-103378 |
| Research Area | Neurological Disease |
| CAS# | 603151-83-3 |
| Purity | ≥98.0% |
| SMILES | CC1=CC2=C3N(N=C(C4=CC=C(Cl)C=C4Cl)C3=N1)C[C@H](CC)N2CC5CC5.OS(=O)(C)=O |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/nbi-35965-methanesulfonate.html |