Cyclosporin A
Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model.Cyclosporin A (NSC 290193) can be used to induce animal models of Chronic Rejection of Liver Transplantation.
| Trivial name | Cyclosporine A, Cyclosporine, Ciclosporin, CsA,NSC 290193 |
| Catalog Number | S2286 |
| Molecular Formula | C11H8FNO2S |
| CAS# | 59865-13-3 |
| Inchi | InChI=1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3- |
| Inchi Key | HWMQHECFXSVZGN-KMKOMSMNSA-N |
| SMILES | C1=CC2=C(C=C1F)C(=CN2)C=C(C(=O)O)S |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/Cyclosporin-A(Cyclosporine-A).html |
| Additional Information | https://file.selleck.cn/downloads/struct/Cyclosporin-A-Cyclosporine-A-chemical-structure-S2286.gif |