Rigosertib
Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle. Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM.
| Trivial name | ON-191 |
| Catalog Number | E7073 |
| Molecular Formula | C10H13N5O4 |
| CAS# | 592542-59-1 |
| Inchi | InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 |
| Inchi Key | OIRDTQYFTABQOQ-KQYNXXCUSA-N |
| SMILES | C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CO)O)O)N |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/rigosertib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7073-rigosertib-chemical-structure-tube.png |