Methotrexate
Methotrexate, analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.
| Trivial name | NCI-C04671, Amethopterin, CL14377, WR19039 |
| Catalog Number | S1210 |
| Molecular Formula | C20H22N8O5 |
| CAS# | 59-05-2 |
| Inchi | InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1 |
| Inchi Key | FBOZXECLQNJBKD-ZDUSSCGKSA-N |
| SMILES | CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/Abitrexate.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Abitrexate-Methotrexate-chemical-structure-S1210.gif |