KU-55933
KU-55933 is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU‑55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy‑initiating kinase ULK1 and results in a significant decrease of autophagy.
| Trivial name | ATM Kinase Inhibitor |
| Catalog Number | S1092 |
| Molecular Formula | C21H17NO3S2 |
| CAS# | 587871-26-9 |
| Inchi | InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2 |
| Inchi Key | XRKYMMUGXMWDAO-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/KU-55933.html |
| Additional Information | https://file.selleck.cn/downloads/struct/KU-55933-chemical-structure-S1092.gif |