KU-55933
KU-55933 is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU‑55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy‑initiating kinase ULK1 and results in a significant decrease of autophagy.
| Trivial name | ATM Kinase Inhibitor |
| Catalog Number | S1092 |
| Molecular Formula | C26H38Cl2N10O4 |
| CAS# | 587871-26-9 |
| Inchi | InChI=1S/C22H30Cl2N10.2C2H4O2/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*1-2(3)4/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2* 1H3,(H,3,4) |
| Inchi Key | WDRFFJWBUDTUCA-UHFFFAOYSA-N |
| SMILES | CC(=O)O.CC(=O)O.C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/KU-55933.html |
| Additional Information | https://file.selleck.cn/downloads/struct/KU-55933-chemical-structure-S1092.gif |