Losmapimod
Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. P38 MAPKs are involved in cell differentiation, apoptosis and autophagy. Phase 3.
| Trivial name | GW856553X, GSK-AHAB |
| Catalog Number | S7215 |
| Molecular Formula | C22 H26 F N3 O2 |
| CAS# | 585543-15-3 |
| Inchi | InChI=1S/C22H26FN3O2/c1-13-17(9-15(10-18(13)23)21(28)26-16-6-7-16)19-8-5-14(11-24-19)20(27)25-12-22(2,3)4/h5,8-11,16H,6-7,12H2,1-4H3,(H,25,27)(H,26,28) |
| Inchi Key | KKYABQBFGDZVNQ-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1F)C(=O)NC2CC2)C3=NC=C(C=C3)C(=O)NCC(C)(C)C |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/losmapimod-gw856553x.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Losmapimod-chemical-structure-s7215.gif |