α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC)[2].IC50 & Target: MC4R[2]In Vitro: α-MSH modulates CNS inflammation by acting directly on melanocortin receptors in glial cells. α-MSH modulates NFκB activation. α-MSH inhibits translocation of transcription factor κB to the nucleus.In Vivo: α-MSH (50 μg/0.2 ml saline; i.p.) given systemically effectively modulates inflammatory reactions.