Hispidol
Hispidol is a potent inhibitor of TNF-α–induced monocyte adhesion to colon epithelial cells with an IC50 of 0.50 μM, and effectively suppresses LPS-induced TNF-α gene expression. Its inhibition of TNF-α is linked to reduced AP-1 transcriptional activity, highlighting its potential as a therapeutic candidate for IBD.
| Trivial name | (Z)-Hispidol |
| Catalog Number | S0248 |
| Molecular Formula | C9H9NO5 |
| CAS# | 5786-54-9 |
| Inchi | InChI=1S/C9H9NO5/c1-14-8-3-6(5-11)7(10(12)13)4-9(8)15-2/h3-5H,1-2H3 |
| Inchi Key | YWSPWKXREVSQCA-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C(=C1)C=O)[N+](=O)[O-])OC |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/hispidol.html |
| Additional Information | https://file.selleck.cn/downloads/struct/S0248-Hispidol-chemical-structure.png |