NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].IC50 & Target:IC50: 0.318 μM (shp2), 0.355 μM (shp1).In Vitro: NSC-87877 (0-0.5 μM, 5 days) inhibits DUSP26 function in NB cell lines.
NSC-87877 (0-0.5 μM, 5 days) results in increased p53 phosphorylation (Ser37 and Ser46) and activation.
In Vivo: NSC-87877 (30?mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity.