Sunitinib
Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.
| Trivial name | SU11248 |
| Catalog Number | S7781 |
| Molecular Formula | C22H27FN4O2 |
| CAS# | 557795-19-4 |
| Inchi | InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- |
| Inchi Key | WINHZLLDWRZWRT-ATVHPVEESA-N |
| SMILES | CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/sunitinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/sunitinib-free-base-chemical-structure-s7781.gif |