Rolapitant
Rolapitant (SCH-619734) is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.
| Trivial name | SCH-619734 |
| Catalog Number | S5476 |
| Molecular Formula | C25H26F6N2O2 |
| CAS# | 552292-08-7 |
| Inchi | InChI=1S/C25H26F6N2O2/c1-16(17-11-19(24(26,27)28)13-20(12-17)25(29,30)31)35-15-23(18-5-3-2-4-6-18)10-9-22(14-32-23)8-7-21(34)33-22/h2-6,11-13,16,32H,7-10,14-15H2,1H3,(H,33,34)/t16-,22-,23-/m1/s1 |
| Inchi Key | FIVSJYGQAIEMOC-ZGNKEGEESA-N |
| SMILES | CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OCC2(CCC3(CCC(=O)N3)CN2)C4=CC=CC=C4 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/rolapitant.html |
| Additional Information | https://file.selleck.cn/downloads/struct/rolapitant-chemical-structure-s5476.gif |