TOFA
TOFA is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA). Inside the cell, TOFA is converted to TOFyl-CoA (5-tetradecyloxy-2-furoyl-CoA), exerting an allosteric inhibition on ACCA. TOFA blocks fatty acid synthesis and induces cell death in a dose-dependent manner.
| Trivial name | 5-(Tetradecyloxy)-2-furoic acid, RMI14514; MDL14514 |
| Catalog Number | S6690 |
| Molecular Formula | C19H32O4 |
| CAS# | 54857-86-2 |
| Inchi | InChI=1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21) |
| Inchi Key | CZRCFAOMWRAFIC-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCOC1=CC=C(O1)C(=O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/tofa-rmi14514.html |
| Additional Information | https://file.selleck.cn/downloads/struct/rmi14514-mdl14514-chemical-structure-s6690.gif |