Lodoxamide
Lodoxamide (U-42585E free acid) is a potent agonist of GPR35 with an EC50 of 1 nM. It also inhibits eosinophil peroxidase release after IgA activation and reduces eosinophil cationic protein and eosinophil-derived neurotoxin, suggesting direct effects on eosinophils. It is a mast cell stabilizer used to treat asthma, allergic conjunctivitis, and superior limbic keratoconjunctivitis.
| Trivial name | U-42585E free acid |
| Catalog Number | E4875 |
| Molecular Formula | C19H23N7O2 |
| CAS# | 53882-12-5 |
| Inchi | InChI=1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13H,2-3,5-8,11H2,(H,20,25)(H,22,23)(H2,21,24,27) |
| Inchi Key | LOLPPWBBNUVNQZ-UHFFFAOYSA-N |
| SMILES | C1CC1NC(=O)NC2=C(NN=C2)C3=NC4=C(N3)C=C(C=C4)CN5CCOCC5 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/lodoxamide.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4875-Lodoxamide-chemical-structure.png |