Rapamycin
Rapamycin is a specific mTOR inhibitor with IC50 of ~0.1 nM in HEK293 cells.Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator and an immunosuppressant.
| Trivial name | Sirolimus, AY-22989, NSC-2260804 |
| Catalog Number | S1039 |
| Molecular Formula | C57H98O6 |
| CAS# | 53123-88-9 |
| Inchi | InChI=1S/C57H98O6/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-43-46-49-55(58)61-52-54(63-57(60)51-48-45-42-39-36-33-30-27-24-21-18-15-12-9-6-3)53-62-56(59)50-47-44-41-38-35-32-29-26-23-20-17-14-11-8-5-2/h 16-21,25-30,54H,4-15,22-24,31-53H2,1-3H3/b19-16-,20-17-,21-18-,28-25-,29-26-,30-27- |
| Inchi Key | HBOQXIRUPVQLKX-BBWANDEASA-N |
| SMILES | CCCCCC=CCC=CCCCCCCCC(=O)OCC(COC(=O)CCCCCCCC=CCC=CCCCCC)OC(=O)CCCCCCCC=CCC=CCCCCC |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/Rapamycin.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Rapamycin-Sirolimus-chemical-structure-S1039.gif |