Mebhydroline
Mebhydroline acts as a selective antagonist of farnesoid X receptor (FXR). Mebhydrolin improves blood glucose balance in in vivo mice models by inhibiting hepatic gluconeogenesis through the FXR/miR-22-3p/PI3K/AKT/FoxO1 pathway and enhancing glycogen synthesis. It also acts as a specific antagonist of histamine H1 receptor. It has potential for its use in the treatment of Type 2 diabetes mellitus (T2DM).
Catalog Number | E4873 |
Molecular Formula | C20H19BrN4O3 |
CAS# | 524-81-2 |
Inchi | InChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1 |
Inchi Key | QBIYUDDJPRGKNJ-UHFFFAOYSA-M |
SMILES | CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-] |
Size | 25mg |
Supplier Page | http://www.selleckchem.com/products/mebhydroline.html |
Additional Information | https://file.selleck.cn/downloads/struct/E4873-Mebhydroline-chemical-structure.png |