SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC50 value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer.IC50 & Target:IC50: 1.3 μM (SRIT2)In Vitro:SIRT2-IN-9 (1-100 μM; 15 min) dose-dependently inhibits SRIT2 with an IC50 value of 1.3 μM, and inhibits SRIT1 and SRIT3 with IC50s ＞300 μM.SIRT2-IN-9 (0-50 μM; 72 h) affects cell viability of MCF-7 cells.SIRT2-IN-9 (0-50 μM; 6 h) affects acetylation of α-tubulin protein.