CGP 57380
CGP 57380 is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. CGP 57380 upregulates β-catenin and potentiates radiation-induced apoptosis.
| Trivial name | N/A |
| Catalog Number | S7421 |
| Molecular Formula | C11H9FN6 |
| CAS# | 522629-08-9 |
| Inchi | InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) |
| Inchi Key | UQPMANVRZYYQMD-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1NC2=C3C(=NC=NC3=NN2)N)F |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/cgp57380.html |
| Additional Information | https://file.selleck.cn/downloads/struct/cgp-57380-chemical-structure-s7421.gif |